A Semianalytic Model of Leukocyte Rolling
نویسندگان
چکیده
منابع مشابه
A semianalytic model of leukocyte rolling.
Rolling allows leukocytes to maintain adhesion to vascular endothelium and to molecularly coated surfaces in flow chambers. Using insights from adhesive dynamics, a computational method for simulating leukocyte rolling and firm adhesion, we have developed a semianalytic model for the steady-state rolling of a leukocyte. After formation in a force-free region of the contact zone, receptor-ligand...
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In Silico White Blood Cell: A Synthetic Model of Leukocyte Rolling, Activation, and Adhesion During Inflammation
We have constructed a synthetic in silico model for representing the dynamics of leukocyte rolling, activation, and adhesion on substrate-coated flow chambers. Software components were designed, instantiated, verified, plugged together, and then operated in ways that can map concretely to mechanisms believed responsible for leukocyte rolling, activation, and adhesion. Here, we show our model’s ...
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Tracking the movement of rolling leukocytes in vivo contributes to the understanding of the mechanism of the inflammatory process and to the development of anti-inflammatory drugs. Several roadblocks exist that hinder successful automated tracking including the moving background, the severe image noise and clutter, the occlusion of the target leukocyte by other leukocytes and structures, the ji...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2004
ISSN: 0006-3495
DOI: 10.1529/biophysj.104.039693